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Measuring circulating tumour DNA can improve bladder cancer treatment

The presence of circulating tumour DNA (ctDNA) is a crucial biomarker for patients with bladder cancer (urothelial carcinoma) researchers have found in a new study. Scientists suggest that post-operative screening for ctDNA could improve cancer treatments and patient outcomes. The authors hope the findings could help improve outcomes for bladder cancer and more broadly illustrates […]

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Promising new immunotherapy for colorectal cancer patients

Patients with advanced colorectal cancer can benefit from treatment with advanced immunotherapy, known as immune checkpoint inhibitor PD-1/PD-L1, scientists have discovered. The findings provide new hope for colorectal cancer patients and more broadly demonstrate the incredible potential for immunotherapies to extend life and treat all forms of cancer. If chemotherapy fails, patients with microsatellite stable […]

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New breast cancer therapy a step closer to clinical trials

An advanced cancer therapy developed by RGCC scientists has been categorised as a Cell Therapy Medicinal Product (CTMP) by the European Medicines Agency (EMA). Tested on breast cancer cells but effective at treating all forms of the disease, the adoptive T cell-based therapy encourages the body’s immune system to target cancer cells. Due to enter clinical trials […]

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Activating p53 protein improves cancer-killing potential

Activating protein p53 can boost a patient’s immune response against cancerous tumours, researchers at Sweden’s Karolinska Institutet have discovered. Using a commercially available substance known as ALRN-6924, the team successfully generated an anti-tumour immune response. The finding improves our understanding of the crucial role p53 plays in tumour development. In the future, it could help […]

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RGCC scientists develop novel new approach to inhibiting SARS-COV-2 replication

RGCC researchers have developed a new approach to tackling COVID-19 (SARS-CoV-2) that could form the basis of a new treatment option. Laboratory tests have established that the new treatments were effective at inhibiting the spread of the disease. The next stage will see them progress to develop a drug delivery system, a further step before […]

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New cancer vaccine effective in 75% of tumours

A new cancer vaccine is 75% effective at eliminating cancerous tumours in mice, say scientists at the University of Konstanz. The combination treatment includes a powerful immunostimulant and a targeted immunotherapy called a cancer checkpoint inhibitor in one dose. Described by the team as a “potent cancer vaccine”, the combination therapy is already being tested […]

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New blood test can diagnose cancer without tumour sample

US scientists have developed the world’s first ‘tumour-uninformed’ test that can detect cancer DNA circulating in the blood of cancer patients following treatment. The liquid biopsy test enables clinicians to test for cancer without needing a sample of tumour tissue. It’s an exciting development and adds yet more evidence to the potential for liquid biopsies […]

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New Genistein capsule offers improved cancer-killing properties

RGCC scientists have developed a new anti-cancer dietary supplement that’s 34% more effective than the leading brand. Led by RGCC’s Dr Ioannis Papasotiriou, the new product offers yet more evidence of the potential for dietary supplements in the battle against cancer. It also demonstrates RGCC’s cutting-edge research and discovery capabilities. Genistein is a naturally occurring […]

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Personalised cancer vaccine 45% effective at targeting tumours

Researchers have developed an effective vaccine that re-engineers cells from a patient’s tumour to target and destroy cancer cells. The results, published in the peer-reviewed Journal of Clinical Oncology, show that 45% of patients treated with an autologous cell vaccine, created from their own cancer cells, had a confirmed anti-tumour response. The findings provide more […]

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Scientists farm natural “cancer-killing” exomes

US researchers have developed the first systemic way to catch and release cancer-killing packets, called exomes. Thousands of times smaller than natural killer (NK) cells, natural killer exomes can better penetrate cancer cells and destroy them. The authors hope that the ability to capture NK exomes could lead to more advanced and personalised treatments for […]

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Cancer mutation test could improve early disease detection

Researchers have developed a new method for assessing whether genetic mutations, passed from parent to child, increase cancer risk. They have identified 1146 genes, called cancer heritability genes (CHGs) that may increase a person’s likelihood of developing cancer during life. The new test could improve early diagnosis and the development of better-targeted treatments for patients. […]

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Scientists develop improved cancer biomarkers

Researchers have developed a new method for identifying biomarkers that could improve diagnosis and improve outcomes for patients. The Cell Heterogeneity-Adjusted cLonal Methylation (CHALM) method developed by scientists enables them to identify biomarkers that may be missed by traditional techniques, potentially leading to more accurate tests for diagnosing cancer. DNA methylation is a genetic process […]

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