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Cancer mutation test could improve early disease detection

Researchers have developed a new method for assessing whether genetic mutations, passed from parent to child, increase cancer risk. They have identified 1146 genes, called cancer heritability genes (CHGs) that may increase a person’s likelihood of developing cancer during life. The new test could improve early diagnosis and the development of better-targeted treatments for patients. […]

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Scientists develop improved cancer biomarkers

Researchers have developed a new method for identifying biomarkers that could improve diagnosis and improve outcomes for patients. The Cell Heterogeneity-Adjusted cLonal Methylation (CHALM) method developed by scientists enables them to identify biomarkers that may be missed by traditional techniques, potentially leading to more accurate tests for diagnosing cancer. DNA methylation is a genetic process […]

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New combination immunotherapy delivers knockout blow to lung cancer

Scientists have discovered that combining two existing forms of immunotherapy together is more effective at treating lung cancer. Working together, the two therapies deliver a one-two punch, targeting and then destroying lung tumour cells. The two-step therapy uses a patients’ immune cells to fight cancer. Scientists extract these “natural killers” from a patients’ tumour or […]

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Scientists identify nine genes associated with breast cancer risk

In the biggest research project of its type ever completed, a European research team has analysed DNA samples from over 100,000 women and identified nine specific genes associated with breast cancer risk. Scientists and experts believe findings could help improve screening and the development of new, personalised treatments for the disease. In an incredible and […]

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CTCs can play a key role in improving metastatic breast cancer treatment

Circulating tumour cells (CTCs) can play a crucial role in improving treatments for metastatic breast cancer, scientists have found. The simple blood test can provide clinicians with a reliable predictor of whether a treatment will be successful in less than a month, an audience at the 2020 San Antonio Breast Cancer Symposium heard in December. […]

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The future of liquid biopsy

UK scientists have discovered that liquid biopsy tests are 99% accurate at picking up crucial genetic mutations in patients with returning breast cancer. Researchers studying the potential for liquid biopsies have concluded that circulating tumour DNA (ctDNA) testing can provide an accurate genomic profile of advanced cancer, without the need for an invasive and potentially […]

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NHS to trial liquid biopsy testing

The UK’s National Health Service (NHS) is to trial a liquid biopsy test that can identify up to 50 forms of cancer. Set to begin in 2021, the pilot project will assess how accurate and effective liquid biopsy testing is at diagnosing the disease. If successful, liquid biopsy testing could be rolled out across the […]

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1 in 8 patients with cancer harbour inherited genetic mutations

A US study of 3,000 cancer patients discovered that 13.5% had an inherited genetic mutation that caused their disease. In most cases, these mutations wouldn’t have been detected by clinicians using a standard guideline-based approach, leaving relatives unaware that they could be at an increased risk of developing cancer in the future. The discovery provides […]

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Liquid biopsies “substantially improve” breast cancer diagnosis

Liquid biopsies have the potential to “substantially help to improve diagnosis” of breast cancer in women, a new study has found. Researchers writing in EBioMedicine (published by world-leading publisher The Lancet) found that “the clinical validity of liquid biopsy in the early breast cancer setting is more than evident.” Liquid biopsy techniques involve analysing a […]

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Cancer gene testing could save millions of lives worldwide

Population-based screening for the BRCA genes that cause ovarian and breast cancer could save millions of lives a year, scientists have found. A new study, published in the journal Cancer, found that population-based genetic testing for BRCA 1 and BRCA 2 genes – where every woman over 30, regardless of risk-factor is screened – was […]

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Unlocking the role of genes in hereditary breast cancer

Mutations in genes only appear in 20% of women offered genetic testing for breast cancer, a new study by University of Melbourne researchers. Previously scientists believed that mutations in known breast cancer genes such as BRCA1 and BRCA2 caused cancer, but in a pioneering study, they were only present in 1 in 5 cases. Instead, […]

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Personalised cancer treatment improves patient outcomes

Patients with advanced cancer were more likely to survive for longer or experience longer periods without disease progression if they received personalised cancer therapy, researchers at the University of California San Diego School of Medicine have found. In a recent trial, three-year survival for cancer patients receiving personalised cancer treatments was 55%, compared to 25% […]

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